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Effects of creatine supplementation on body composition and renal function in rats. Ferreira LG, De Toledo Bergamaschi C, Lazaretti-Castro M, Heilberg IP Nephrology Division, Universidade Federal de São Paulo, Brazil. Abstract: BACKGROUND: The aim of the present study was to evaluate the long-term effects of oral creatine supplementation on renal function and body composition (fat and lean mass) in an experimental model. METHODS: Male Wistar rats were supplemented with creatine (2 g.kg(-1) of food) for 10 wk in combination with treadmill exercise, 12 m.min(-1), 1 h.d(-1) (CREAT + EX, N = 12) or not (CREAT, N = 10), and compared with exercised animals without creatine supplementation (EX, N = 7) and CONTROL animals, N = 7. Body composition and bone mineral density (BMD) were determined by dual x-ray absorptiometry and glomerular filtration rate (GFR) and renal plasma flow (RPF) were measured by inulin and paraaminohippurate clearance, respectively. RESULTS: At the end of the study (post), CREAT+EX presented higher lean mass and lower fat mass than CREAT, EX or CONTROL (349.7 +/- 19.7 vs 313.3 +/- 20.3, 311.9 +/- 30.8, 312.4 +/- 21.0 g and 5.7 +/- 2.3 vs 10.0 +/- 3.3, 9.8 +/- 1.5, 10.0 +/- 3.5%, P < 0.05, respectively). Post lean/fat mass ratio was higher than baseline only in CREAT + EX (18.9 +/- 7.2 vs 8.6 +/- 1.8, P < 0.05). Post BMD was significantly higher than baseline in all groups. GFR and RPF were lower in CREAT versus CONTROL (0.5 +/- 0.1 vs 1.0 +/- 0.1 and 1.5 +/- 0.2 vs 2.4 +/- 0.5 mL.min(-1), P < 0.05, respectively). CONCLUSION: Creatine supplement in combination with exercise increased the proportion of lean mass more than EX or CREAT alone. The use of creatine alone induced an important and significant reduction of both RPF and GFR. Commento: non so quanto possa essere comparato un protocollo del genere (2g/100gr cibo) per 10 settimane ad un trattamento a lungo termine in un essere umano. L'unico parametro di cui sono a conoscenza è che un ratto raggiunge un massimo di un centinaio di gr di peso, e che la durata media della vita è di due anni e mezzo, per cui 10 settimane (2 mesi e mezzo) equivalgono a circa il 10% della durata media di vita del ratto (se ho fatto bene i calcoli. se li ho sbagliati abbiate pietà che ho fame e sto lavorando come na ciuccia) :lookaround: p.s.: ho messo in bold le parti per me importanti.
Effects of creatine supplementation on body composition and renal function in rats. Ferreira LG, De Toledo Bergamaschi C, Lazaretti-Castro M, Heilberg IP Nephrology Division, Universidade Federal de S&atilde;o Paulo, Brazil. Abstract: BACKGROUND: The aim of the present study was to evaluate the long-term effects of oral creatine supplementation on renal function and body composition (fat and lean mass) in an experimental model. METHODS: Male Wistar rats were supplemented with creatine (2 g.kg(-1) of food) for 10 wk in combination with treadmill exercise, 12 m.min(-1), 1 h.d(-1) (CREAT + EX, N = 12) or not (CREAT, N = 10), and compared with exercised animals without creatine supplementation (EX, N = 7) and CONTROL animals, N = 7. Body composition and bone mineral density (BMD) were determined by dual x-ray absorptiometry and glomerular filtration rate (GFR) and renal plasma flow (RPF) were measured by inulin and paraaminohippurate clearance, respectively. RESULTS: At the end of the study (post), CREAT+EX presented higher lean mass and lower fat mass than CREAT, EX or CONTROL (349.7 +/- 19.7 vs 313.3 +/- 20.3, 311.9 +/- 30.8, 312.4 +/- 21.0 g and 5.7 +/- 2.3 vs 10.0 +/- 3.3, 9.8 +/- 1.5, 10.0 +/- 3.5%, P &lt; 0.05, respectively). Post lean/fat mass ratio was higher than baseline only in CREAT + EX (18.9 +/- 7.2 vs 8.6 +/- 1.8, P &lt; 0.05). Post BMD was significantly higher than baseline in all groups. GFR and RPF were lower in CREAT versus CONTROL (0.5 +/- 0.1 vs 1.0 +/- 0.1 and 1.5 +/- 0.2 vs 2.4 +/- 0.5 mL.min(-1), P &lt; 0.05, respectively). CONCLUSION: Creatine supplement in combination with exercise increased the proportion of lean mass more than EX or CREAT alone. The use of creatine alone induced an important and significant reduction of both RPF and GFR. Commento: non so quanto possa essere comparato un protocollo del genere (2g/100gr cibo) per 10 settimane ad un trattamento a lungo termine in un essere umano. L&#039;unico parametro di cui sono a conoscenza &egrave; che un ratto raggiunge un massimo di un centinaio di gr di peso, e che la durata media della vita &egrave; di due anni e mezzo, per cui 10 settimane (2 mesi e mezzo) equivalgono a circa il 10% della durata media di vita del ratto (se ho fatto bene i calcoli. se li ho sbagliati abbiate piet&agrave; che ho fame e sto lavorando come na ciuccia) :lookaround: p.s.: ho messo in bold le parti per me importanti.
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