Advertisement
La review in questione è uscita in gennaio su Journal of Gene Medicine 2008 Jan;10(1):3-20 Titolo: Developing strategies for detection of gene doping Autori: Baoutina A, Alexander IE, Rasko JE, Emslie KR Abstract: "It is feared that the use of gene transfer technology to enhance athletic performance, the practice that has received the term 'gene doping', may soon become a real threat to the world of sport. As recognised by the anti-doping community, gene doping, like doping in any form, undermines principles of fair play in sport and most importantly, involves major health risks to athletes who partake in gene doping. One attraction of gene doping for such athletes and their entourage lies in the apparent difficulty of detecting its use. Since the realisation of the threat of gene doping to sport in 2001, the anti-doping community and scientists from different disciplines concerned with potential misuse of gene therapy technologies for performance enhancement have focused extensive efforts on developing robust methods for gene doping detection which could be used by the World Anti-Doping Agency to monitor athletes and would meet the requirements of a legally defensible test. Here we review the approaches and technologies which are being evaluated for the detection of gene doping, as well as for monitoring the efficacy of legitimate gene therapy, in relation to the detection target, the type of sample required for analysis and detection methods. We examine the accumulated knowledge on responses of the body, at both cellular and systemic levels, to gene transfer and evaluate strategies for gene doping detection based on current knowledge of gene technology, immunology, transcriptomics, proteomics, biochemistry and physiology." Commento: Gli autori descrivono le metodiche sviluppate per scoprire l'utilizzo di doping genetico. Le misure sono divise tra 1) Tipo diretto: - Transgenic protein detection - Vector detection 2)Tipo indiretto: - Immune responses to gene transfer - Profiling approaches 3)In vivo non-invasive imaging
La review in questione è uscita in gennaio su Journal of Gene Medicine 2008 Jan;10(1):3-20 Titolo: Developing strategies for detection of gene doping Autori: Baoutina A, Alexander IE, Rasko JE, Emslie KR Abstract: "It is feared that the use of gene transfer technology to enhance athletic performance, the practice that has received the term 'gene doping', may soon become a real threat to the world of sport. As recognised by the anti-doping community, gene doping, like doping in any form, undermines principles of fair play in sport and most importantly, involves major health risks to athletes who partake in gene doping. One attraction of gene doping for such athletes and their entourage lies in the apparent difficulty of detecting its use. Since the realisation of the threat of gene doping to sport in 2001, the anti-doping community and scientists from different disciplines concerned with potential misuse of gene therapy technologies for performance enhancement have focused extensive efforts on developing robust methods for gene doping detection which could be used by the World Anti-Doping Agency to monitor athletes and would meet the requirements of a legally defensible test. Here we review the approaches and technologies which are being evaluated for the detection of gene doping, as well as for monitoring the efficacy of legitimate gene therapy, in relation to the detection target, the type of sample required for analysis and detection methods. We examine the accumulated knowledge on responses of the body, at both cellular and systemic levels, to gene transfer and evaluate strategies for gene doping detection based on current knowledge of gene technology, immunology, transcriptomics, proteomics, biochemistry and physiology." Commento: Gli autori descrivono le metodiche sviluppate per scoprire l'utilizzo di doping genetico. Le misure sono divise tra 1) Tipo diretto: - Transgenic protein detection - Vector detection 2)Tipo indiretto: - Immune responses to gene transfer - Profiling approaches 3)In vivo non-invasive imaging
modificato Aug 25 '08 a 10:55 pm
 
0
risposta
mi piacerebbe leggerlo per intero, ma qualcosa mi dice che i miei ricordi di genetica hanno delle pesanti ragnatele :asd:
mi piacerebbe leggerlo per intero, ma qualcosa mi dice che i miei ricordi di genetica hanno delle pesanti ragnatele :asd:
modificato Aug 26 '08 a 10:39 pm
 
0
risposta
Dettagli Discussione
28
viste
1 risposte
0 followers
anteprima immediata
inserisci almeno 10 caratteri
ATTENZIONE: Hai menzionato %MENTIONS%, ma non possono vedere questo messaggio e non ne riceveranno notifica
Salvataggio...
Salvato
With selected deselect posts show selected posts
Tutti i messaggi di questo argomento saranno cancellato ?
Bozza in attesa ... Click per tornare alla modifica
Elimina la bozza